Promethazine (HCl) is an antihistamine, employed in the treatment of hypersensitivity reaction and allergic conjunctivitis and for prevention of allergic reactions to blood or plasma in patients with a better-known history of such reactions, promethazine (HCl) is employed as an antiemetic to stop nausea and vomiting. and additionally used for pre-operative and postoperative sedation.
- Promethazine will cause breathing issues in young kids. It mustn’t be employed in children younger than 2 years. In children this age, this drug might cause slowed respiration that may lead to death. Caution ought to be used once giving this drug to children older than 2 years. Also, this drug mustn’t be utilized in children who are taking alternative medicine that may cause slowed breathing.
Mechanism
- Promethazine works by preventing the release of a substance referred to as histamine from certain cells in your body. histamine is generally released once you’re exposed to things you’re allergic to, like pollen, dander, mold, or chemicals. Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the digestive tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea seems to be related with central anticholinergic actions and should implicate activity on the medullary chemoreceptor trigger zone.
Promethazine Side effects
- Common Side Effects of promethazine Include;Drowsiness, Dizziness,Dry mouth,Stuffy nose, Blurred vision,Constipation, Ringing within the ears,Impotence or hassle having an orgasm, Weight gain while Serious Side Effects of this drug include; Uncontrolled movements of your eyes, lips, Restlessness or feeling edgy or agitated, tongue, face, legs, or arms, Uncontrolled shaking, trouble with balance or walking, issues swallowing or drooling, Seizure, Feeling like you may pass out, Pale skin, Vision issues or raised sensitivity to light, Fever, Bruising or bleeding easily,Hallucinations, influenza symptoms,Nausea/stomach pain,Sore throat,jaundice, Skin rash, issues with urination,Swollen glands, Joint pain and swelling.
Pregnancy
- There aren’t any adequate studies of promethazine in pregnant women. Administration of antihistamine within two weeks of delivery might have an effect on platelet function in the newborn. It is not better-known whether or not promethazine is excreted in breast milk.
Dose
- Allergic reactions are treated with 6.25-25 mg orally three times daily. one 25 mg dose administered at bedtime additionally may suffice. A 25 mg injection is additionally used. Nausea and vomiting may be managed with 12.5-25 mg administered orally by injection each 4-6 hours as required.