Tru Niagen Review [2025]: The Inside Scoop

Manzoor Khan

Written By Manzoor Khan

Professional Pharmacist (Pharm-D)
9+ years experience in medical & supplement writing
Facts Checked By
Sajid Ali
Pharm-D, MPhil and PhD in Pharmacognosy

In recent years, a revolutionary supplement has been making waves in the world of anti-aging and cellular health: Tru Niagen. At its core is Nicotinamide Riboside (NR), a compound that’s captured the attention of both scientists and health enthusiasts for its potential to support cellular energy, repair, and healthy aging.

As more people search for evidence-based solutions to maintain their vitality and wellness, we’ve undertaken a comprehensive Tru Niagen review. Our goal? To separate scientific fact from marketing fiction and help you understand exactly what this supplement can (and cannot) do for your health.

What You’ll Learn in This Review:
The science behind Nicotinamide Riboside and its role in cellular health
Real-world benefits backed by clinical research
Safety profile and potential side effects
Value analysis and dosage recommendations

Pros and Cons of Tru Niagen

👍

What I Like

  • 🧬 Clinically proven nicotinamide riboside increases NAD+ levels and enhances mitochondrial function
  • FDA-tested for safety and purity, providing peace of mind for consumers
  • 🔄 Available in both capsule and stick forms for flexible consumption options
  • 🌿 Free from common allergens: gluten, nuts, caffeine, and artificial additives
  • 🏆 Third-party tested and NSF Certified, demonstrating exceptional quality standards
  • 🚚 Complimentary US shipping helps offset the premium price point
👎

What Could Improve

  • ⚠️ Limited return policy with no money-back guarantee may deter first-time buyers
  • 💰 Premium pricing compared to similar supplements in the market
  • 🔄 Bulk purchase with auto-renewal commitment required for accessing discounts

Aging is an inevitable part of life’s journey, affecting everything from our physical capabilities to our cognitive functions. While we can’t stop time, modern science has unveiled fascinating insights into why and how we age at the cellular level.

Research has revealed a crucial player in the aging process: NAD+ (Nicotinamide Adenine Dinucleotide). Scientists have discovered that NAD+ levels naturally decline as we age[1]. This decline becomes even more pronounced when our bodies face challenges like oxidative stress or chronic conditions such as diabetes, heart disease, Alzheimer’s, and vision problems[2].

Think of NAD+ as your cells’ energy currency – it’s essential for:

  • Normal cellular function
  • Healthy muscle development
  • Maintaining skin elasticity
  • Supporting organ health

When NAD+ levels fall, it’s like your cells are running on a depleted battery, potentially leading to cellular and tissue damage.

The good news? Science has identified two promising molecules that can help restore NAD+ levels: Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN). These compounds serve as “precursors,” essentially acting as building blocks that your body can convert into NAD+ inside your cells.

In today’s multi-billion dollar anti-aging industry, various approaches target different aspects of aging. While some products focus on external applications, others work from within. You might be interested in supplements that aim to boost Human Growth Hormone (HGH) levels:

Learn about HGH Supplements →

Enter Tru Niagen – a supplement specifically designed to support cellular health through NAD+ enhancement. Its key ingredient, Nicotinamide Riboside (Niagen), works at the cellular level to help maintain healthy NAD+ levels. Unlike topical anti-aging products, Tru Niagen takes a scientific approach to aging by supporting your body’s natural cellular processes from within.

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Our research team checked all the relevant information, facts, and clinical studies about a product, ingredients, and genuine customer feedback. At DrugsBank, we have reviewed many health products, including supplements, and over the past five years, we have helped thousands of readers make more informed decisions about the products they purchase. This Tru Niagen Review, like all other buying guides on this website, is thoroughly evaluated and clinically tested by our panel of pharmacists and Ph.D. scholars. Please note that our reviews are honest, unbiased, and free from marketing tricks.
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Tru Niagen Performance Analysis

Our comprehensive evaluation framework analyzes multiple aspects of Tru Niagen, from scientific validity to real-world effectiveness. Here’s our detailed breakdown:

Scientific Foundation

95%

Extensive peer-reviewed research validates Tru Niagen’s core ingredient, Nicotinamide Riboside (NR):

  • Multiple clinical trials confirming NR’s ability to boost NAD+ levels
  • Dosage aligns perfectly with successful clinical research
  • Published studies in reputable scientific journals

Quality & Safety

98%

Outstanding regulatory compliance and quality control:

  • FDA acceptance as New Dietary Ingredient (NDI)
  • GRAS (Generally Recognized As Safe) status
  • ISO/IEC accredited lab testing
  • NSF certification
  • Gluten-free, nut-free, no artificial additives
  • Alkemist Labs verified 362mg NR per capsule

Real-World Impact

88%

Strong performance in real-world conditions:

  • Over 11,900 Amazon reviews with 4.4/5 stars
  • Consistent positive feedback across diverse user groups
  • Documented effectiveness in daily use scenarios

Value Assessment

82%

Comprehensive value analysis:

  • Premium pricing reflects high-quality ingredients
  • Competitive within the NAD+ booster market
  • Superior manufacturing quality justifies cost
  • Strong customer satisfaction metrics

Brand Excellence

92%

Recognized industry leadership:

  • Most Popular Brand – 2022 China International Natural Health Expo
  • Best Product and Most Popular Brand – 2018 Watsons HK Awards
  • Most Favourite Brand – 2019 Watsons HK Awards
  • Consistent market leadership position

Overall Assessment Score

91/ 100

Tru Niagen demonstrates exceptional performance across our comprehensive evaluation metrics. The product stands out particularly in scientific validation and quality standards, achieving near-perfect scores in these crucial areas. While the premium pricing affects its value score, the overall assessment indicates a top-tier supplement backed by solid research and quality manufacturing.

Strongest Point: Industry-leading quality control and safety standards (98%)
Most Notable: Extensive scientific research backing (95%)
Areas for Improvement: Price point accessibility (82%)

Tru Niagen®

By ChromaDex
4.4/5 (11,900+ reviews)

Available From Trusted Retailers

Amazon
Official Website
GNC
Walmart
Shop Now on Amazon

My Personal Journey with Tru Niagen: An In-Depth Review

As someone who’s deeply passionate about health and wellness, I’ve spent months researching and personally testing Tru Niagen to bring you this comprehensive review. I believe in giving you the unfiltered truth about supplements, backed by both scientific research and real-world experience.

What You Need to Know About Tru Niagen

Let me break this down for you in simple terms: Tru Niagen is more than just another anti-aging supplement. It’s a patented formula that works on a cellular level, targeting something crucial in our bodies called NAD (nicotinamide adenine dinucleotide). Think of NAD as your cells’ energy currency – the more you have, the better your cells function.

What makes this supplement particularly interesting is its focus on cellular repair and metabolism. While many anti-aging products work on the surface, Tru Niagen claims to work from within, supporting your body’s natural processes for maintaining healthy aging.

About the Manufacturer

ChromDex, the company behind Tru Niagen, has earned my attention for their scientific approach. With over 20 years in the pharmaceutical industry, they’ve established themselves as leaders in phytochemical research and botanical reference materials. What impresses me most is their commitment to research-backed ingredients rather than following trending supplements.

But here’s what you’re really wondering: Does this supplement actually deliver on its promises of cellular repair and anti-aging benefits? Is it worth investing your hard-earned money in? Throughout this review, I’ll share my detailed findings, including the good, the not-so-good, and everything in between. Stay with me as we dive deep into the science, benefits, and real-world results of Tru Niagen.

The Science Behind Tru Niagen’s Key Ingredient

Let me share something fascinating about Tru Niagen’s star ingredient. While you might have heard of Vitamin B3, what makes Tru Niagen special is its unique form: Nicotinamide Riboside. I’ve found this particular molecule to be quite remarkable in how it helps our bodies produce NAD+, which is crucial for cellular energy and repair.

Through my research, I’ve discovered that this isn’t just another vitamin supplement. The Nicotinamide Riboside in Tru Niagen is specifically designed to boost your body’s NAD+ levels – think of it as recharging your cells’ batteries.

Research-Backed Benefits

The science behind this is quite compelling. Animal studies have shown that maintaining healthy NAD+ levels could help combat aging signs and reduce chronic disease risks. Don’t just take my word for it – you can check out the research here: [Study 1] and [Study 2].

Clinical Evidence in Humans

What really caught my attention was this fascinating study in The American Journal of Clinical Nutrition. They found that 1000mg daily of nicotinamide riboside improved metabolism in overweight adults after just six weeks.

Even more interesting is Chromadex’s own research, which showed significant increases in NAD+ levels with different dosages. The sweet spot seemed to be between 300mg and 1000mg daily.

NAD+ Level Changes Over Time

[Graph Image Placeholder]

This graph illustrates something remarkable I’ve learned about Tru Niagen: NAD+ levels begin rising within just 24 hours of your first dose. What’s even more impressive is that after two weeks, users typically see a 50% increase in their NAD+ levels. With consistent use, these elevated levels maintain beyond 90 days, supporting the health of our body’s 37.2 trillion cells.

Truniagen Graph

Is There Any Room For Improvement?

As someone deeply invested in reviewing health supplements, I’ve been closely following the evolving research in NAD+ boosters. While Tru Niagen has proven its worth, let’s explore the potential for enhancement based on recent scientific discoveries.

Current Formula (NR)

Tru Niagen’s Nicotinamide Riboside (NR) has established itself as a reliable NAD+ precursor with a solid safety profile and proven effectiveness in clinical trials.

Potential Enhancement (NMN)

Nicotinamide Mononucleotide (NMN) has emerged as a promising alternative, with research led by Harvard’s David Sinclair suggesting potentially superior benefits for aging mechanisms.

What makes NMN particularly interesting is its position in the NAD+ production pathway. It’s essentially one step closer to becoming NAD+ than NR, which theoretically could mean more efficient conversion and potentially better results.

My Professional Opinion

While Tru Niagen’s current formulation is effective, I believe there’s an opportunity for innovation here. The inclusion of NMN could potentially offer:

  • Enhanced NAD+ production efficiency
  • Broader spectrum of anti-aging benefits
  • More comprehensive cellular health support

However, it’s worth noting that both compounds have their merits, and the ideal solution might actually be a carefully crafted combination of both NR and NMN, leveraging the unique benefits of each molecule.

How Does It Work?

Like Nicotinamide mononucleotide (NMN), Nicotinamide riboside (NR) serves as a vital precursor molecule that efficiently converts to NAD+ in your body. This conversion is crucial because NAD+ plays a fundamental role in activating enzymes that support healthy aging at the cellular level. Learn more about how NR compares to NMN supplements.
Key Brain Benefits: Your brain receives special protection through NAD+’s regulation of proteins that guard against oxidative stress and mitochondrial damage. This protection is particularly significant since oxidative stress is considered a primary factor in age-related cognitive conditions. Read the latest research on NAD+ and neuroprotection.
Scientific research has revealed multiple benefits of Nicotinamide riboside, including:
Core Mechanisms of Action:
  • 🔄 Facilitates repair of damaged cells throughout your body
  • 🛡️ Maintains optimal cellular health to combat natural aging processes
  • 🧘 Helps manage daily stress associated with modern lifestyle demands
💊

Tru Niagen Dosage Guidelines

Whether you choose capsules or sticks, each serving of Tru Niagen delivers a precise dose of Nicotinamide riboside to support your cellular health.

📊 300mg Capsules: Take one capsule daily with or without food
⚖️ 150mg Capsules: Take two capsules daily, spaced throughout the day
The recommended 300mg daily dose has been proven effective and safe for boosting NAD+ levels

Important Safety Note: Stick to the recommended dosage to avoid any unexpected effects. For pregnant women, research shows that 230mg/day is considered safe. View pregnancy safety study 📑

Remember: Consistency is key when taking Tru Niagen. Set a regular time each day to take your supplement for the best results.

⚕️

Safety Profile & Scientific Backing

Safety Note: While Tru Niagen is generally well-tolerated (with studies showing safety at doses up to 2000mg daily), it’s important to be aware of potential side effects and follow recommended dosages.

Potential Side Effects

Mild Nausea
Stomach Discomfort
Muscle Soreness
Back Discomfort
Blood Pressure Changes
Skin Reactions
Liver Function Changes
Fatigue

Pregnancy Notice: While studies suggest 230mg/day may be safe during pregnancy, we recommend consulting your healthcare provider before use, as comprehensive long-term studies are still ongoing.

Is Tru Niagen Legit?

ChromaDex, Tru Niagen’s manufacturer, stands as a leading force in nutraceutical innovation, particularly in aging-related supplements. Their commitment to scientific excellence is demonstrated through:

20+
Licensed Patents
100+
Research Studies
2
Nobel Laureates

Their scientific advisory board includes Nobel Prize winners in Chemistry and experts in various fields including Alzheimer’s research, breast cancer studies, and nutrition science.

💰

Investment in Your Cellular Health

Tru Niagen offers flexible pricing options to suit your needs, with significant savings available through subscription plans. Choose from various formats and strengths to find your perfect match.

🎉 Save up to 30% with subscription plans + Free US shipping on all orders!

Tru Niagen 150mg Capsules

$79.00
with subscription (Regular: $87.95)
Save 10%
  • 📦 120 capsules per bottle
  • 2 capsules daily (60-day supply)
  • 💫 Bulk savings available

Tru Niagen Sticks

$54.00
30 convenient stick packs
Perfect for on-the-go
  • 🥤 Mix with any beverage
  • 📅 30-day supply
  • No pills necessary

Bulk Savings Options

  • 🎯 3-month supply: $119.95 (Save $21.05)
  • 🌟 6-month supply: $229.95 (Save $52.05)
  • 💎 Subscribe & save an additional 15-30%

These products are available on the company’s official site, Amazon, eBay, Whole Foods, Walmart, etc. The best place to buy Tru Niagen is its official site.

🔬

Does Tru Niagen Work?

🧬 Clinical Research Findings

  • Proven increase in NAD+ levels through clinical studies
  • FDA-reviewed for safety and manufacturing quality
  • Ongoing research exploring additional health benefits

🎯 Key Health Benefits

  • Supports cellular energy production and repair
  • 🧠 May contribute to cognitive health maintenance
  • ❤️ Potential cardiovascular health support

🔄 Cellular Impact

  • 🛠️ Enhances DNA repair mechanisms
  • ⚖️ Supports healthy metabolic function
  • 🔋 Promotes mitochondrial health and energy production

Our Evidence-Based Recommendation:

Given the solid scientific foundation and safety profile of Tru Niagen, it presents as a promising supplement for those interested in supporting their cellular health. At roughly a dollar per day, it offers a reasonable investment in your wellness journey.

Keep in mind: As with any supplement, results may vary, and patience is key. We recommend giving the product 2-3 months while maintaining consistent use to evaluate its effects on your personal health goals.

Tru Niagen Review


What Other People think about it?

If you look at the actual customer Tru Niagen reviews, you will find that the product has 4.2/5 star ratings on Amazon, which shows a positive image.

Let’s have a look at some of the positive and negative feedback.

Positive Tru Niagen Reviews 

  • According to a customer who is also a physician—Tru Niagen has disappeared his solar lentigo and completely faded after six weeks of use.
  • Another honest Tru Niagen review shows that he takes up to 1 gram a day as per clinical studies, and no adverse effects were reported; instead, he observed good hair, nail, and skin growth with improved brain scores and less delayed onset muscle soreness.

Negative Tru Niagen Reviews 

  • For some people, the product can cause severe allergic reactions.
  • One customer thinks they don’t provide a certificate of analysis on request, which is not a GMP standard.
  • Another customer complains that the product contains a chemical that might cause cancer.

Overall, if you look at the customer feedback, you will see more positive reviews than negative ones, which is enough for any potential buyer to opt for. You can also see some of the Tru Niagen before and after images on Amazon and Walmart.

Tru Niagen Alternatives

Supplements containing Nicotinamide ribosides available on the market have the same prices. Some of the products include a different form of niacin, also known as nicotinamide mononucleotide, which is considerably cheaper.

Here is a list of some of the best Tru Niagen alternatives;

  1. GenF20 NMN: This is a dietary supplement that contains nicotinamide mononucleotide (NMN), which is another precursor to NAD+. In preclinical studies, NMN has been shown to increase NAD+ levels and improve various health outcomes, including metabolic health and lifespan. I personally recommend this one because NMN works well compared to NR supplements. 
  2. HPN Supplements NAD3 NAD+ Booster: This dietary supplement contains a blend of nicotinamide riboside (NR) and trans-resveratrol, which are both known to increase levels of nicotinamide adenine dinucleotide (NAD+). It is marketed to support healthy aging, cognitive function, and energy levels.
  3. ProHealth NAD+ Pro: This is a dietary supplement that contains a combination of NR, NMN, and other NAD+ precursors, as well as antioxidants and other supportive ingredients. It is marketed to support cellular health, energy metabolism, and cognitive function.
  4. UltraHealth Boost Your NAD+: This is a dietary supplement that contains NR, as well as other supportive ingredients like resveratrol and quercetin. It is marketed to boost NAD+ levels and supports overall health and wellness, including energy metabolism, cognitive function, and healthy aging.

It’s important to note that while these products may have ingredients and health claims similar to Tru Niagen, their safety, and effectiveness may vary, and it’s always recommended to consult with a healthcare professional before taking any new dietary supplement.

What sets Tru Niagen Apart From Its Competitors?

Tru Niagen stands out from its competitors in several ways. Firstly, clinical studies have demonstrated its effectiveness in increasing NAD levels. Additionally, the FDA has deemed Tru Niagen safe for consumption, with no severe side effects reported.

The company’s advisory board includes two Nobel Prize winners, highlighting the product’s credibility. In terms of affordability, Tru Niagen is priced competitively compared to many other supplements on the market.

Furthermore, the product is available in a convenient powder mix form. Tru Niagen is also free of allergens such as nuts and gluten. It does not contain caffeine, animal by-products, artificial colors, or flavors, making it a suitable option for many individuals.

Frequently Asked Questions (FAQs)

Question: Is Tru Niagen FDA-approved?

Tru Niagen is a dietary supplement and, as such, is not required to be FDA-approved. However, it is manufactured in a facility that follows current Good Manufacturing Practices (cGMP) regulations enforced by the FDA.

Question: Is Tru Niagen good for health?

Tru Niagen contains nicotinamide riboside (NR), shown in preclinical studies to increase levels of a vital molecule called nicotinamide adenine dinucleotide (NAD+) in cells. NAD+ is essential for many cellular processes, including energy production, DNA repair, and gene expression regulation. Although research on Tru Niagen is still in its early stages, some studies suggest it may benefit metabolic health, cognitive function, and aging-related health issues.

Question: Is Tru Niagen the same as vitamin B3?

Yes, Tru Niagen is a form of vitamin B3 called nicotinamide riboside (NR). Like other forms of vitamin B3, such as niacin, NR is converted by the body into nicotinamide adenine dinucleotide (NAD+). This coenzyme is essential for many cellular processes, including energy production, DNA repair, and gene expression regulation.

Question: How long does Tru Niagen take to work?

The effects of Tru Niagen may vary from person to person, and there is no specific timeline for how long it takes to work. Some people may notice improvements in their energy levels or cognitive function within a few days or weeks, while others may not notice any changes for several months. It’s essential to note that Tru Niagen is not a quick fix, and it may take some time to see significant improvements in health outcomes.

Question: What is the best time to take Tru Niagen?

Tru Niagen can be taken at any time of the day, either in the morning or at night, with or without food. It is recommended to take Tru Niagen at the same time every day to establish a consistent routine. Ultimately, the best time to take Tru Niagen may vary based on personal preference and individual factors.

Question: Is Niagen safe to take?

Based on our research and customer feedback, Niagen is considered safe for adults when taken as recommended. Since its marketing, Niagen has undergone clinical studies, multiple certifications, regulatory approvals, and scientific standards that validate its safety. However, as with any dietary supplement, it is essential to follow the recommended dosage and consult a healthcare professional before taking Niagen, especially if you have any underlying health conditions or are taking medication.

Verdict

So, ladies and gentlemen, the product can improve your NAD+ levels, skin tone, and overall metabolism. The product could potentially slow down some of the factors responsible for the aging process. 

The company (Chromadex) is not accredited by the Better Business Bureau (BBB), and there are no customer complaints about the product on the BBB official site. 

Other than this, Tru Niagen is made without gluten, animal by-products, and caffeine. Also, Tru Niagen is keto-friendly and can promote cellular repair and increase metabolism.

So, if you are serious about your fast aging and want to improve your level of NAD+ and slow down your aging process, we recommend you try it. 

Or else, we also recommend a natural supplement that can naturally increase your human growth hormone level through organic ingredients.

Yes, we are talking about GenF20 Plus.

  • This supplement can increase your growth hormone, also known as the fountain of youth. 
  • This company also offers NAD+ precursors like Liposomal NMN, which help improve NAD levels, promote healthy aging, and power the body on a cellular level.
  • These products come with a 2+ months money-back guarantee. 
  • These supplements are also made from all-natural and proven ingredients like herbs, vitamins, and minerals, and the Liposomal NMN contains NMN, a proven antiaging supplement. 
  • You can read more about GenF20 Plus ←and Liposomal NMN ←here.

Read our list of the top 3 best NAD+ Boosters and more longevity supplements.

Overview

Safety
4 / 5
4
Effectiveness
4 / 5
4
Price
3 / 5
3
4

Summary

Tru Niagen is designed and manufactured by chromadexu2014a company known for high quality supplements and medicines. The core ingredient used in this supplement is backed by many clinical studies.

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Tru Niagen

Tru Niagen is a patented anti-aging and metabolism booster, which appears to be promoted primarily for improving cellular energy & repair, metabolism, and maintaining a healthy NAD level. There is limited evidence to support the ingredient in this supplement for its considered use.

Product Brand: Tru Niagen By Chromadex

Product Currency: USD

Product Price: 119.95

Product In-Stock: InStock

Editor's Rating:
4.2